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教师队伍
 
芦秀丽 教授
2014-05-06 15:22     (点击: )

 

 

芦秀丽  教授、博士生导师

学习经历

2003.04 – 2008.03  日本名古屋大学医学研究科细胞情报医学专业 博士、博士后

1992.09 – 1997.07 中国成都中医药大学药学院药理专业 学士

工作经历

2008.04 – 至今       辽宁大学生命科学院 教授、博士生导师

2015.05 – 2016.05   美国德克萨斯大学奥斯汀分校 访问学者

2001.07 – 2003.03   日本爱知医科大学药理学教室 外国人研究员

1997.07 – 2001.05   北京卫生职业学院(原北京中医学校)教师

研究方向

  1. 生物大分子结构与功能研究
  2. 基础细胞信号转导与应激
  3. 疾病分子机制研究
  4. 生物制药及新药筛选与研发

获奖情况

  1. 辽宁省高等学校优秀人才
  2. 2013年度辽宁省科学技术奖励自然科学奖二等奖(No. 2013Z-2-01-02)
  3. 2016年度沈阳市科技进步奖一等奖(No.2016-J-1-16-2)

主持的主要科研项目

  1. 国家自然基金面上项目(31271494)
  2. 国家自然基金青年项目(30800575)
  3. 教育部留学回国人员科研启动基金
  4. 辽宁省高等学学校杰出青年学者成长计划(LJQ2011004)
  5. 沈阳市人才资源开发专项基金资助项目
  6. 日本21世纪COE青年奖励研究基金

国家发明专利

  1. 申请发明专利:一种以24-脱氢胆固醇还原酶(DHCR24)为靶点进行降胆固醇药物的虚拟筛选方法(201710105026.6)
  2. 授权发明专利:组织特异性表达的24-脱氢胆固醇还原酶编码重组腺病毒(201210113722.9)
  3. 授权发明专利:一种以人乳头瘤病毒HPV的DNA解旋酶E1为靶点的抗HPV病毒药物的虚拟筛选方法(201210195233.2)
  4. 授权发明专利:以keap1为靶点的新型防癌抗癌药物虚拟筛选方法(201010246499.8)

发表的主要SCI期刊收录论文

  1. Xiuli Lu, Deliang Sun, Bo Xu, Jichuan Pan,Yanhong Wei, Xu Mao, Daojun Yu, Hongsheng Liu, Bing Gao. In silico screening and molecular dynamic study on nsSNPs associated with kidney stone in SLC26A6 gene. Journal of Urology. 2016 Jan 23. 2016, 196(1):118-123 (SCI 泌尿与肾病1区, Top期刊,IF 4.5)
  2. Xiaoping Quan, Xiuqiang Chen, Deliang Sun, Bo Xu, Linlin Zhao, Xiaoqian Shi, Hongsheng Liu, Bing Gao, Xiuli Lu(通讯作者),The Mechanism of the Effect of U18666a on Blocking the Activity of 3β-hydroxysterol Δ-24-reductase (DHCR24): Molecular Dynamics Simulation Study and Free Energy Analysis,Journal of Molecular Modeling, 2016, 22(2):1-12 (SCI 计算机跨学科应用 2区)
  3. Xiuli Lu, Dan jia, Ting Liu,Chenguang Zhao, Shuchao Chen, Weiqi Wang, Bing Gao, Recombinant Adenovirus-Mediated High Expression of DHCR24 specially in Neuronal cells and its Functional Analysis, Neural Regeneration Research, 2014, 9(5):504-512, (SCI 收录)
  4. Xiuli Lu, Yang Li, Weiqi Wang, Shuchao Chen, Ting Liu,Dan Jia, Xiaoping Quan, Deliang Sun, Alan Chang, Bing Gao, 3 β-Hydroxysteroid-Δ 24 Reductase (DHCR24) Protects Neuronal Cells from Apoptotic Cell Death Induced by Endoplasmic Reticulum (ER) Stress. PLoS One. 2014 Jan 29;9(1):e86753(SCI综合科学 1区)引用次数:7次
  5. Xiuli Lu,Yong Zhang,Shuchao Chen,Yang Li,Ting Liu,Dan Jia,Weiqi Wang,Bing Gao,Hongsheng Liu,Molecular Dynamics Simulation Study on the Mechanism of the Inhibition of ATP Hydrolysis with Inhibitors in Human Papillomavirus Type 18 E1 Helicase,Advances in Intelligent Systems Research2013, May 23;45-47 (EI收录)
  6. Xiuli Lu, Bing Gao, Takahiro Yasui, Yang Li, Ting Liu, Xu Mao, Masahito Hirose, Yuhong Wu, Daojun Yu, Qiwen Zhu, Kenjiro Kohri,Chunling Xiao,Matrix Gla protein is involved in crystal formation in kidney of hyperoxaluric rats, Kidney & Blood Pressure Research, 2013;37(1):15-23. (SCI 生理学2区)引用次数:6次
  7. Xiuli Lu, Bing Gao, Youliang Wang, Zehui Liu, Takahiro Yasui, Ping Liu, Jian Liu, Newton Emmanuel, Qiwen Zhu & Chunling Xiao. Renal tubular epithelial cell injury, apoptosis and inflammation are involved in melamine-related kidney stone formation. Urol Res., 2012 Dec;40(6):717-23.
  8. Xiuli Lu, Bing Gao, Zehui Liu, Xiurong Tian, Xu Mao, Newton Emmanuel, Qiwen Zhu & Chunling Xiao. A Polymorphism of Matrix Gla Protein Gene Is Associated With Kidney Stone In Chinese Han population. Gene. 2012 Dec 15;511(2):127-30. (SCI基因与遗传3区)引用次数:9次
  9. Xiuli Lu, Shuchao Chen, Yong Zhang, Li Zhang, Hongsheng Liu, Bing Gao,The Discovery of Direct Noncovalent Bonded Interaction between Keap1 and Diethyl Maleate through Molecular Dynamics Simulations,Applied Mechanics and Materials,2012,195,260-265 (EI收录)
  10. Xiuli Lu, Yang Li, Jianli Liu, Xiangyu Cao, Xude Wang, Delong Wang, Bing Gao, The membrane topological analysis of 3 β-hydroxysteroid-delta24 reductase(DHCR24)on endoplasmic reticulum, Journal of Molecular Endocrinology, 2012 Jan 25;48(1):1-9. (SCI医学2区,IF 3.6)引用次数:8次
  11. Xiuli Lu, Jianli Liu, Fangfang Hou, Zhenqing Liu, Xiangyu Cao, Hisao Seo, Bing Gao,Cholesterol induces pancreatic b cell apoptosis through oxidative stress pathway,Cell Stress and chaperon, 2011 Sep;16(5):539-48(SCI细胞生物学3区, IF 3.2)引用次数:30次
  12. Xiuli Lu, Shuchao Chen, Yong Zhang, Fangtong Li, Xiaohui Sun, Bing Gao,Study of Expanded Application of Molecular Docking on Virtual Screening, International Conference on Bioengineering, Chemistry and Environment Science (BCES 2011, Vol. 9: 7863-7866)(EI收录)
  13. Xiuli Lu,Jianli Liu,Xiangyu Cao,Xiao Hou,Xude Wang,Yang Li, Ting Liu,Bing Gao,Hisao Seo, Native low density lipoprotein induces pancreatic b cell apoptosis through generating excess reactive oxygen species, Lipid in health and disease, 2011 Jul 26;10:123 (SCI收录, IF 2.2)
  14. Xiuli Lu, Kambe F, Cao X, Yamauti M, Seo H: DHCR24 is a hydrogen peroxide-scavenger, protecting cells from oxidative stress-induced apoptosis. Endocrinology. 2008 Jul;149(7):3267-73. Epub 2008 Mar 13. (IF 5.2) 引用次数:50次
  15. Xiuli Lu, Kambe F, Cao X, Yamamoto T, Seo H: Insulin-like growth factor-I stimulates neuronal cell survival by activating Akt through its cognate receptor present in caveolae. Experimental Cell Research, 2008 Jan 15;314(2):342-51 (IF 3.8) 引用次数:28次
  16. Xiuli Lu, Kambe F, Cao X, Yoshida T, Ohmori S, Murakami K, Kaji T, Ishii T, Zadworny D, Seo H: DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology. 2006 Jun; 147(6): 3123-32 (IF 5.2) 引用次数:52次

主要教学情况

主讲本科生分子生物学、神经生物学中英双语教学主干课程;

主讲硕士研究生细胞信号转导课程课程;

承担博士研究生高级分子生物学、高级生物信息学主讲课程;

获得辽宁省教学成果奖二等奖1项;承担教学改革项目1项;发表高校教学论文2篇。

 

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