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毕秀丽 博士生导师
2019-07-17 08:24  
姓  名:毕秀丽
职  称:教授
电子邮件:xiulibi@lnu.edu.cn
 

教育背景

1996.09 ~ 2000.07 河北医科大学药学专业 学士学位

2000.09 ~ 2005.07 沈阳药科大学药理学专业 硕博连读

工作经历

2011.04 ~ 至今   辽宁大学生命科学院任教

2017.09 ~ 2018.09  加拿大麦吉尔大学古德曼肿瘤研究中心 访问教授

2007.02 ~ 2010.11  美国伊利诺斯大学芝加哥分校任助理研究员 讲师

2005.08 ~ 2007.02  美国阿拉巴马大学 药理和毒理系博士后

讲授课程

本科生:先后为本科生讲授过基因工程、动物生理学课程。

研究生:先后开设了现代生物学进展、细胞增殖调控与肿瘤、细胞信号转导课程。

研究兴趣

肠道肿瘤的分子发生机制及预防,侧重肠道菌群及表观遗传调控在结直肠肿瘤的发生发展机制研究,及以此为靶点的肿瘤预防和治疗;肿瘤药物的临床前研发。

Alezheimer’s Disease 为代表的神经退行疾病的分子机制及临床前药物研发

奖励荣誉

辽宁省“兴辽英才计划”青年拔尖人才

2012 “NFCR-USCACA Scholar”

辽宁省“百千万人才工程”“百”层次

辽宁省高校优秀人才

学术成果

1、Mao L, Yang J, Yue J, Chen Y, Zhou H, Fan D, Zhang Q, Buraschi S, Iozzo R.V., Bi X*. Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis. Matrix Biology.2020 (Accepted for publication) (*corresponding author)

2、Zhou H, Yang Z, Yue J, Chen Y, Chen T, Mu T, Liu H, Bi X*. Identification of potential hub genes via bioinformatics analysis combined with experimental verification in colorectal cancer. Mol Carcinog. 2020 Apr;59(4):425-438. (*corresponding author)

3、Li L, Ghorbani M, Weisz-Hubshman M, Rousseau J, Thiffault I, Schnur RE, Breen C, Oegema R, Weiss MM, Waisfisz Q, Welner S, Kingston H, Hills JA, Boon EM, Basel-Salmon L, Konen O, Goldberg-Stern H, Bazak L, Tzur S, Jin J, Bi X, Bruccoleri M, McWalter K, Cho MT, Scarano M, Schaefer GB, Brooks SS, Hughes SS, van Gassen KLI, van Hagen JM, Pandita TK, Agrawal PB, Campeau PM, Yang XJ. Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability. J Clin Invest. 2020 Mar 2;130(3):1431-1445.

4、Guo J, Yang Z, Zhou H, Yue J, Mu T, Zhang Q, Bi X*. Upregulation of DKK3 by miR-483-3p plays an important role in the chemoprevention of colorectal cancer mediated by black raspberry anthocyanins. Mol Carcinog. 2020 Feb;59(2):168-178. (*corresponding author)

5、Zhang H, Guo J, Mao L, Li Q, Guo M, Mu T, Zhang Q, Bi X*. Up-regulation of miR-24-1-5p is involved in the chemoprevention of colorectal cancer by black raspberry anthocyanins. Br J Nutr. 2019 122(5):518-526. (*corresponding author)

6、Chen L, Jiang B, Zhong C, Guo J, Zhang L, Mu T, Zhang Q, Bi X*. Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation. Carcinogenesis. 2018 39(3), 471–481 (*corresponding author)

7、Xiao T, Guo Z, Bi X#, Zhao Y, Polyphenolic profile as well as anti-oxidant and anti-diabetes effects of extracts from freeze-dried black raspberries Journal of Functional Foods 2017 (31): 179–187.  (# co-corresponding author)

8、Bi X, Shi Q, Zhang H, Bao Y, Hu D, Pohl N, Fang W, Dong H, Xia X, Fan D, Yang W. c-Jun NH2-teminal kinase 1 interacts with vitamin D receptor and affects vitamin D-mediated inhibition of cancer cell proliferation. J Steroid Biochem Mol Biol. 2016 Oct;163:164-72.

9、Bi X*, Xia X, Fan D, Mu T, Zhang Q, Iozzo RV, Yang W. Oncogenic activin C interacts with decorin in colorectal cancer in vivo and in vitro. Mol Carcinog. 2016 Nov;55(11):1786-1795.  (*corresponding author)

10、Zhong C, Jiang C, Xia X, Mu T, Wei L, Lou Y, Zhang X, Zhao Y, Bi X*. Antihepatic Fibrosis Effect of Active Components Isolated from Green Asparagus (Asparagus officinalis L.) Involves the Inactivation of Hepatic Stellate Cells. J Agric Food Chem. 2015 63(26):6027-34. (*corresponding author)

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